Fluocinolone acetonide( NSC 92339 )

Catalog No. M15588 CAS No. 67-73-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Fluocinolone acetonide
Note

Research use only, not for human use.
Brief Description

Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
Description

Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
In Vitro

Cell Proliferation Assay Cell Line:DCPs Concentration:0.1 μmol/L, 1 μmol/L, 10 μmol/L, 20 μmol/L, 40 μmol/L, 60 μmol/L, 100 μmol/L Incubation Time:24 h Result:Significantly promoted the growth rate of DPCs of a low concentration.Western Blot Analysis Cell Line:DCPs Concentration:1 μmol/L, 10 μmol/L Incubation Time:7 days Result:Showed higher expressions of DSPP and Wnt4 protein than negative control.
In Vivo

Animal Model:PTX-induced peripheral neuropathy model Dosage:500 μg/kg Administration:Intraperitoneal injection (i.p.)Result:Prevented a marked reduction in intraepidermal nerve fibers density in the plantar surface of the hind paws.
Synonyms

NSC 92339
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

67-73-2
Formula Weight

452.49
Molecular Formula

C24H30F2O6
Purity

>98% (HPLC)
Solubility

Ethanol: 12 mg/mL (26.51 mM); DMSO: 90 mg/mL (198.89 mM)
SMILES

O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@]5(C(CO)=O)OC(C)(C)O[C@]5([H])C[C@@]4([H])[C@]3([H])C[C@H](F)C2=C1
Chemical Name

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one